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Reframing sexual differentiation of the brain

MM McCarthy, AP Arnold - Nature Neuroscience, 2011 - nature.com
In the twentieth century, the dominant model of sexual differentiation stated that genetic sex
(XX versus XY) causes differentiation of the gonads, which then secrete gonadal hormones that
act directly on tissues to induce sex differences in function. This serial model of sexual ...
Cited by 2 - All 3 versions

β-Catenin is essential for Müllerian duct regression during male sexual differentiation

A Kobayashi, CA Stewart, Y Wang, K Fujioka… - …, 2011 - dev.biologists.org
During male sexual differentiation, the transforming growth factor-β (TGF-β) signaling molecule
anti-Müllerian hormone (AMH; also known as Müllerian inhibiting substance, MIS) is secreted
by the fetal testes and induces regression of the Müllerian ducts, the primordia of the ...
Cited by 2 - Related articles - All 3 versions

Mode of sexual differentiation and its influence on the relative sensitivity of the fathead minnow and zebrafish in the fish sexual development test

KL Thorpe, H Schiffer, P Burkhardt-Holm… - Aquatic Toxicology, 2011 - Elsevier
Exogenous treatment of fish with natural sex hormones and their mimics has been shown to
influence gonadal differentiation resulting in biased phenotypic sex-ratios. This has lead to the
development of the Fish Sexual Development Test (FSDT) as a method for the detection ...

Dipentyl Phthalate Dosing during Sexual Differentiation Disrupts Fetal Testis Function and Postnatal Development of the Male Sprague-Dawley Rat with Greater …

BR Hannas, J Furr, CS Lambright… - Toxicological …, 2011 - Soc Toxicology
Phthalate esters (PEs) constitute a large class of plasticizer compounds that are widely used
for many consumer product applications. Ten or more members of the PE class of compounds
are known to induce male fetal endocrine toxicity and postnatal reproductive ...
Cited by 2 - Related articles - All 4 versions

Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation

NL Manuylov, B Zhou, Q Ma, SC Fox, WT Pu… - Developmental …, 2011 - Elsevier
Assembly of functioning testis and ovary requires a GATA4-FOG2 transcriptional complex. To
define the separate roles for GATA4 and FOG2 proteins in sexual development of the testis we
have ablated the corresponding genes in somatic gonadal cells. We have established ...
All 2 versions

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