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Brivanib, an FGF/VEGF inhibitor, is differentially active 1st vs. 2nd line against mouse PNET tumors developing evasive/adaptive resistance to VEGF inhibition

Check for Full TextE Allen, I Walters… - Clinical Cancer Research, 2011 - AACR
... evasive/adaptive resistance to VEGF inhibition ... 1 Brivanib, a dual FGF/VEGF inhibitor,
is active both 1st and 2nd line against mouse pancreatic neuroendocrine tumors (PNET)
developing adaptive/evasive resistance to VEGF inhibition ...
Related articles - All 2 versions

… FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition

Check for Full TextE Allen, IB Walters… - Clinical Cancer Research, 2011 - AACR
Experimental Design: An anti-VEGFR2 monoclonal antibody (DC101), an inhibitor of FGF signaling
(FGF ligand trap), sorafenib, and brivanib were comparatively evaluated in first-line monotherapy
in short and longer term fixed endpoint intervention trials in the RIP-Tag2 mouse model of ...
Cited by 2

Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic …

Check for Full TextSH Millson, CS Chua, SM Roe, S Polier… - The FASEB Journal, 2011 - FASEB
ABSTRACT Much attention is focused on the benzo- quinone ansamycins as anticancer
agents, with several derivatives of the natural product geldanamycin (GdA) now in clinical
trials. These drugs are selective inhibi- tors of Hsp90, a molecular chaperone vital for ...

Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals

[HTML] from nih.gov
Check for Full TextR Rabøl, KF Petersen, S Dufour… - Proceedings of the …, 2011 - National Acad Sciences
Skeletal muscle insulin resistance has been implicated in the pathogenesis of nonalcoholic fatty
liver disease (NAFLD) and atherogenic dyslipidemia associated with the metabolic syndrome
by altering the distribution pattern of postprandial energy storage. We conducted a study ...

CD4+ CD25+ Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

[PDF] from nyu.edu
Check for Full TextP Pandiyan, HR Conti, L Zheng, AC Peterson… - Immunity, 2011 - Elsevier
Th17 cells and CD4 + CD25 + Foxp3 + regulatory T (Treg) cells are thought to promote and suppress
inflammatory responses, respectively. Here we explore why under Th17 cell polarizing
conditions, Treg cells did not suppress, but rather upregulated, the expression of ...
Cited by 7 - Related articles - All 3 versions

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