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Calreticulin Inhibits Prion Protein PrP-(23–98) Aggregation in Vitro

N SHIRAISHI, Y INAI, Y HIRANO… - Bioscience, Biotechnology, …, 2011 - J-STAGE
Because prion protein PrP-(23–98) was recently found to polymerize into amyloid-like and
proteinase K-resistant spherical aggregates in the presence of NADPH plus copper ions, we
tested to determine whether calreticulin (CRT) inhibits PrP-(23–98) aggregation in vitro. ...

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles

[PDF] from umass.eduSE Encalada, L Szpankowski, C Xia… - Cell, 2011 - Elsevier
Kinesin and dynein are opposite-polarity microtubule motors that drive the tightly regulated
transport of a variety of cargoes. Both motors can bind to cargo, but their overall composition
on axonal vesicles and whether this composition directly modulates transport activity are ...
Cited by 3 - Related articles - All 3 versions

Alzheimer's Disease Brain-Derived Amyloid-β-Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

[HTML] from cjb.netAE Barry, I Klyubin, JM Mc Donald… - The Journal of …, 2011 - Soc Neuroscience
Synthetic amyloid-β protein (Aβ) oligomers bind with high affinity to cellular prion protein (PrP
C ), but the role of this interaction in mediating the disruption of synaptic plasticity by such soluble
Aβ in vitro is controversial. Here we report that intracerebroventricular injection of Aβ- ...
Cited by 1 - Related articles - All 5 versions

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

UK Resenberger, A Harmeier, AC Woerner… - The EMBO …, 2011 - nature.com
Formation of aberrant protein conformers is a common pathological denominator of different
neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover, increasing
evidence indicates that soluble oligomers are associated with early pathological ...
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[HTML] Presence and Seeding Activity of Pathological Prion Protein (PrPTSE) in Skeletal Muscles of White-Tailed Deer Infected with Chronic Wasting Disease

[HTML] from plos.orgML Daus, J Breyer, K Wagenfuehr, WM Wemheuer… - PloS one, 2011 - dx.plos.org
Chronic wasting disease (CWD) is a contagious, rapidly spreading transmissible spongiform
encephalopathy (TSE), or prion disease, occurring in cervids such as white tailed-deer
(WTD), mule deer or elk in North America. Despite efficient horizontal transmission of ...
Related articles - Cached - All 3 versions

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