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Gene Therapy for Mesothelioma

A Vachani, E Moon… - Current Treatment Options in Oncology, 2011 - Springer
... Adeno-associated virus The adeno-associated virus (AAV) [8, 9] is a defective parvovirus with
a single strand DNA genome and a naked protein coat. AAV has not been associated with any
known human disease state, suggesting a significant safety margin for this vector. ...
All 3 versions

Structure of a Packaging-Defective Mutant of Minute Virus of Mice Indicates that the Genome Is Packaged via a Pore at a 5-Fold Axis

P Plevka, S Hafenstein, L Li, A D'Abrgamo Jr… - Journal of …, 2011 - Am Soc Microbiol
... While some of these modifications rendered capsids temperature sensitive or unconditionally
defective for assembly and/or subsequent cell entry, one mutant (L172W ... pore, indicating that
the channel along one of the 5-fold axes is the packaging portal for the parvovirus genome ...
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[HTML] Mitotic Catastrophe Occurs in the Absence of Apoptosis in p53-Null Cells with a Defective G1 Checkpoint

[HTML] from plos.orgM Fragkos… - PloS one, 2011 - dx.plos.org
... In this work we have probed cell death in mitosis by using a virus, adeno-associated
virus (AAV), which is a replication-defective parvovirus containing a 4.7 kb
single-stranded DNA genome [26]. AAV can induce a DNA damage ...
Cached

Recombinant-adeno-associated viral vector-mediated gene therapy for cardiovascular diseases.

M Zhang, H Yuan, Z Huang… - Zhong nan da xue xue bao. Yi …, 2011 - ncbi.nlm.nih.gov
... Center of Clinical Pharmacology, Third Xiangya Hospital; School of Pharmaceutical Sciences,
Central South University, Changsha 410013, China. Objective Methods Results Conclusion
Adeno-associated virus is a kind of DNA defective parvovirus which is non-pathogenic. ...

Methods and compounds for controlled release of recombinant parvovirus vectors

PE Monahan, RJ Samulski… - US Patent 7,923,436, 2011 - Google Patents
... 12, 2011 (54) METHODS AND COMPOUNDS FOR CONTROLLED RELEASE OF RECOMBINANT
PARVOVIRUS VECTORS (75) Inventors: Paul E. Monahan, Chapel Hill, NC (US); Richard Jude
Samulski, Chapel Hill, NC (US); Joseph E. Rabinowitz, Carrboro, NC (US) (73 ...
Related articles - All 3 versions

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