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Alternative Ubiquitin Activation/Conjugation Cascades Interact with N-End Rule Ubiquitin Ligases to Control Degradation of RGS Proteins

PCW Lee, ME Sowa, SP Gygi… - Molecular Cell, 2011 - Elsevier
Vertebrates express two enzymes for activation of ubiquitin—UBA1, which is responsible for
activation of the vast majority of E2 conjugating enzymes, and UBA6, which uses the
dedicated E2, USE1. However, targets and E3s for UBA6-USE1 are unknown. Here, we ...

Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation

A Chatterjee, CM Johnson, CC Shu… - Proceedings of the …, 2011 - National Acad Sciences
Convergent gene pairs with head-to-head configurations are widespread in both eukaryotic and
prokaryotic genomes and are speculated to be involved in gene regulation. Here we present
a unique mechanism of gene regulation due to convergent transcription from the ...
Cited by 3 - Related articles - All 3 versions

Small Ubiquitin-like Modifier (SUMO) Conjugation Impedes Transcriptional Silencing by the Polycomb Group Repressor Sex Comb on Midleg

M Smith, DR Mallin, JA Simon… - Journal of Biological Chemistry, 2011 - ASBMB
The Drosophila protein Sex Comb on Midleg (Scm) is a member of the Polycomb group
(PcG), a set of transcriptional repressors that maintain silencing of homeotic genes during
development. Recent findings have identified PcG proteins both as targets for ...
Cited by 1 - Related articles

The steady-state repertoire of human SCF Ubiquitin ligase complexes does not require ongoing Nedd8 conjugation

[HTML] from nih.govJE Lee, MJ Sweredoski, RLJ Graham… - Molecular & Cellular …, 2011 - ASBMB
The human genome encodes 69 different F-box proteins (FBPs), each of which can potentially
assemble with Skp1-Cul1-RING to serve as the substrate specificity subunit of an SCF ubiquitin
ligase complex. SCF activity is switched on by conjugation of the ubiquitin-like protein ...
Cited by 2 - Related articles - All 6 versions

SUMO conjugation of STAT1 protects cells from hyper-responsiveness to interferon-{gamma}

A Begitt, M Droescher, KP Knobeloch… - Blood, 2011 - ncbi.nlm.nih.gov
The biological effects of interferon-γ (IFNγ) are mediated by the transcription factor STAT1. The
activity of STAT1 is inhibited by SUMO conjugation. This occurs both directly through decreasing
STAT1 tyrosine phosphorylation, and indirectly by facilitating STAT1 dephosphorylation ...
Cited by 1

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