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Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins

[HTML] from nih.govF Ruiz-Perez, R Wahid… - Proceedings of the …, 2011 - National Acad Sciences
The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic
Gram-negative bacteria through the autotransporter pathway. We previously classified SPATE
proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). Here, we show ...
Cited by 1

Transient Suppression of Shigella flexneri Type 3 Secretion by a Protective O-Antigen-Specific Monoclonal IgA

[HTML] from asm.orgSJ Forbes, T Bumpus, EA McCarthy, B Corthésy… - mBio, 2011 - Am Soc Microbiol
Mucosal immunity to the enteric pathogen Shigella flexneri is mediated by secretory IgA
(S-IgA) antibodies directed against the O-antigen (O-Ag) side chain of lipopolysaccharide. While
secretory antibodies against the O-Ag are known to prevent bacterial invasion of the ...
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Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates

JK Simon, M Maciel Jr, ED Weld, R Wahid… - Clinical …, 2011 - Elsevier
We studied the induction of antigen-specific IgA memory B cells (BM) in volunteers who
received live attenuated Shigella flexneri 2a vaccines. Subjects ingested a single oral dose
of 107, 108 or 109 CFU of S. flexneri 2a with deletions in guaBA (CVD 1204) or in guaBA, ...
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The Shigella flexneri Type Three Secretion System Effector IpgD Inhibits T Cell Migration by Manipulating Host Phosphoinositide Metabolism

C Konradt, E Frigimelica, K Nothelfer, A Puhar… - Cell Host & Microbe, 2011 - Elsevier
Shigella, the Gram-negative enteroinvasive bacterium that causes shigellosis, relies on its type
III secretion system (TTSS) and injected effectors to modulate host cell functions. However, consequences
of the interaction between Shigella and lymphocytes have not been investigated. We ...
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A multifactor regulatory circuit involving H-NS, VirF and an antisense RNA modulates transcription of the virulence gene icsA of Shigella flexneri

CN Tran, M Giangrossi, G Prosseda… - Nucleic Acids …, 2011 - Oxford Univ Press
The icsA gene of Shigella encodes a structural protein involved in colonization of the intestinal
mucosa by bacteria. This gene is expressed upon invasion of the host and is controlled by a
complex regulatory circuit involving the nucleoid protein H-NS, the AraC-like ...
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