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Aprotinin and similar protease inhibitors as drugs against Influenza

OP Zhirnov, HD Klenk… - Antiviral Research, 2011 - Elsevier
Efforts to develop new antiviral chemotherapeutic approaches are focusing on compounds that
target either influenza virus replication itself or host factor(s) that are critical to influenza
replication. Host protease mediated influenza hemagglutinin (HA) cleavage is critical for ...

Switch from aprotinin to ɛ-aminocaproic acid: impact on blood loss, transfusion, and clinical outcome in neonates undergoing cardiac surgery

K Martin, R Gertler, H Liermann… - British Journal of …, 2011 - British Jrnl Anaesthesia
Background With the withdrawal of aprotinin from worldwide marketing in November 2007, many
institutions treating patients at high risk for hyperfibrinolysis had to update their therapeutic
protocols. At our institution, the standard was switched from aprotinin to ɛ-aminocaproic ...

Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era

A Koster… - Current Opinion in Anesthesiology, 2011 - journals.lww.com
Purpose of review: Hemorrhage, transfusions and the need for re-exploration can have a detrimental
effect on patient outcome in cardiac surgery. With the suspension of aprotinin from the
market, only the antifibrinolytics tranexamic acid and epsilon-aminocaproic acid (EACA) ...
Cited by 1 - Related articles - All 4 versions

Aprotinin Decreases Lung Reperfusion Injury and Dysfunction

HB Bittner, PS Dahlberg, CS Herrington… - Principles of Pulmonary …, 2011 - Springer
Reduced lung perfusion and subsequent pulmonary isch- emia can cause increased pulmonary
vascular resistance, decreased oxygenation capacity, worsened compliance, and edema
formation. The initial ischemic insult to the lung correlates with the production of cytokines ...
Related articles - All 2 versions

Postoperative complications following the fontan procedure: the role of aprotinin

D Klugman, MT Donofrio, D Zurakowski… - Perfusion, 2011 - prf.sagepub.com
Since its initial description in 1971, the Fontan proce- dure1 and the postoperative management
of single ven- tricle patients have improved significantly. Fluid dynamic studies2,3, as well as
surgical innovations by de Leval, Jonas and Castaneda, led to the lateral tunnel Fontan, ...

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