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Azathioprine/allopurinol co-therapy is an effective treatment for patients with inflammatory bowel disease who exhibit no response or side-effects to thiopurines without …

P Stamoulos, A Ansari, J Stenner, G Mackenzie… - Gut, 2011 - gut.bmj.com
Introduction In Inflammatory bowel disease (IBD) lack of response or side effects to thiopurines
(TP: azathioprine and mercaptopurine) are common (30–50%) and frequently necessitate surgery
or use of biologic agents (£10 000–15 000/patient/year). It is assumed that low dose ...

6-Thioguanine measurement allows optimisation in management of IBD patients on azathioprine

GE Dolman, HE Johnson, SD McLaughlin… - Gut, 2011 - gut.bmj.com
Introduction Azathioprine is widely used in the management of Inflammatory Bowel Disease
(IBD). The ideal dose for a patient is usually calculated by weight, but the rate of metabolism
of azathioprine to its active metabolite 6-thioguanine (6TGN) varies between individuals. ...
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Azathioprine maintenance therapy in IBD: medium term outcomes from a nurse-delivered IBD monitoring service at a district general hospital

HE Johnson, SD McLaughlin… - Gut, 2011 - gut.bmj.com
Methods A prospective data base of IBD patients has been maintained at our unit since
2005. The authors reviewed the cases of all IBD patients commencing azathioprine treatment
between June 2005 and December 2007 and followed up for at least 3 years. Thiopurine ...

* Azathioprine metabolites in autoimmune hepatitis: relationship with therapeutic efficacy

RJ Anderson, HK Dhaliwal, S Schneider… - Gut, 2011 - gut.bmj.com
Introduction Long term azathioprine (AZA, 2 mg/kg/day) is used to maintain remission in Autoimmune
Hepatitis (AIH). However 10–20% of patients are unresponsive to AZA. AZA is a pro-drug and
formation of the active metabolite (thioguanine nucleotides-TGNs) varies between ...

Association Between Adverse Effects Under Azathioprine Therapy and Inosine Triphosphate Pyrophosphatase Activity in Patients With Chronic Inflammatory Bowel …

M Shipkova, J Franz, M Abe, C Klett… - Therapeutic Drug …, 2011 - journals.lww.com
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