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The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

YH Paik, K Iwaisako, E Seki, S Inokuchi… - …, 2011 - Wiley Online Library
Although NOX plays an important role in HSC activation and hepatic fibrosis, how various NOX
homologues expressed in different hepatic cell types contribute to hepatic fibrogenesis is
unknown. The purpose of the present study was to investigate the contributory role of ...
Cited by 1 - Related articles - All 3 versions

On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside

C Brenner - Journal of Biological Chemistry, 2011 - ASBMB
In a study aimed at identifying factors contributing to nicotinamide riboside (NmR) metabolism
in yeast, Drs. Lu and Lin prepared a cellular extract by bead-beating in ice-cold 50 mm ammonium
acetate (1). In Figs. 1–4, they added this extract to an NmR-dependent yeast strain and ...
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Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network

V Audrito, T Vaisitti, D Rossi, D Gottardi, G D'Arena… - Cancer Research, 2011 - AACR
Because of its relatively indolent clinical course, chronic lymphocytic leukemia (CLL) offers a
versatile model for testing novel therapeutic regimens and drug combinations. Nicotinamide
is the main NAD + precursor and a direct inhibitor of four classes of enzymes, including ...
Cited by 1 - Related articles - All 3 versions

Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene

R Tao, D Wei, H Gao, Y Liu, RA DePinho… - Journal of Biological …, 2011 - ASBMB
FoxO transcription factors have been implicated in lipid metabolism; however, the underlying
mechanisms are not well understood. Here, in an effort to elucidate such mechanisms, we examined
the phenotypic consequences of liver-specific deletion of three members of the FoxO ...
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Nicotinamide Phosphoribosyltransferase Is Essential for Interleukin-1β-mediated Dedifferentiation of Articular Chondrocytes via SIRT1 and Extracellular Signal- …

EH Hong, HS Yun, J Kim, HD Um, KH Lee… - Journal of Biological …, 2011 - ASBMB
Although much is known about interleukin (IL)-1β and its role as a key mediator of cartilage destruction
in osteoarthritis, only limited information is available on IL-1β signaling in chondrocyte
dedifferentiation. Here, we have characterized the molecular mechanisms leading to the ...

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