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Characterization of pentoxyverine metabolites in urine using GC/MS after intoxication with SilomatŪ cough drops

F Westphal, T Junge, L Radünz, J Stegk… - Forensic Science …, 2011 - Elsevier
... In the urine sample high amounts of pentoxyverine (carbetapentane) and several of its metabolites,
eg, different hydrolyzed, desalkylated and ring-hydroxylated products have been identified. ... Fig.
1. Structure of pentoxyverine (carbetapentane), later referred to as compound 15. ...
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Potent inhibition of anoxic depolarization by the sodium channel blocker dibucaine

HA Douglas, JK Callaway, J Sword… - Journal of …, 2011 - Am Physiological Soc
... Previous studies showed that certain ligands that bind σ-1 receptors can delay AD, especially
carbetapentane (Anderson et al. ... This was 10 times the potency of the σ-1 receptor ligand
carbetapentane, the drug that we previously found best inhibited AD in slices (Anderson et al. ...
Cited by 1 - Related articles - All 3 versions

Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging

Z Li, HY Ren, MC Cui, W Deuther-Conrad… - Bioorganic & medicinal …, 2011 - Elsevier
... of brain disease. 12 The effect of DHEAS on persistent sodium currents was also
eliminated by 1 receptor blockers, and the 1 receptor agonist carbetapentane citrate
was found to mimic the effect of DHEAS. The main functional ...
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The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium

M Ghasemi… - Trends in Pharmacological Sciences, 2011 - Elsevier
... NMDAR blockers and the glutamate release inhibitor carbetapentane inhibited
lithium-induced IP 3 accumulation in the same tissues [31], suggesting that lithium
acutely stimulates glutamate availability in the synaptic cleft. ...
Related articles - All 2 versions

Invitation for public comment-ACMS and ACCS meetings, June 2011

SMP - 2011 - tga.gov.au
... cough and cold products only where it will not result in less restrictive scheduling:
Carbetapentane (pentoxyverine); Guaiphenesin (guaifenesin); Ipecacuanha
(cephaelis acuminata and cephaelis ipecacuanha); Phenylephrine; ...
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