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Multistage nanoparticle delivery system for deep penetration into tumor tissue

[HTML] from pnas.orgC Wong, T Stylianopoulos, J Cui… - Proceedings of the …, 2011 - National Acad Sciences
... matrix. Therefore, we propose a multistage system in which 100-nm nanoparticles
“shrink” to 10-nm nanoparticles after they extravasate from leaky regions of the tumor
vasculature and are exposed to the tumor microenvironment. ...
Cited by 8 - Related articles - All 4 versions

Extravasation of a Therapeutic Dose of 131I-Metaiodobenzylguanidine: Prevention, Dosimetry, and Mitigation

DV Bonta, RK Halkar… - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
... RESULTS Dosimetry In human models of extravasation using small volumes (5 mL), residual
extravasate was still present at 42 min but ... The resulting extravasate thickness of 1.2 cm (60
mL/50 cm2), ensures that charged particle equilibrium is a reasonable assump- tion. ...

Basic Science Offers a Challenge for Developing Hemoglobin Based Oxygen Carriers into Therapeutic Agents

E Bucci - Artificial Cells, Blood Substitutes and …, 2011 - informahealthcare.com
... These data suggested that only when HBOCs extravasate into the muscle layer of the
vessels does scavenging of NO result in systemic vasoconstriction. Extravasation of
infused HBOCs occurs through large pores of capillary beds. ...
Related articles - All 2 versions

[HTML] Quantitative model for efficient temporal targeting of tumor cells and neovasculature

[HTML] from hindawi.comH CA - Computational and mathematical methods in medicine, 2011 - hindawi.com
... The nanocells extravasate into the tumor through the enhanced permeation and retention
(EPR) effect [20, 21] (see Figure 1), a consequence of the highly leaky nature of tumor
vasculature (having pores with diameters of 400–600 nm). ...
Related articles - Cached - All 10 versions

The blood-brain barrier, chemokines and multiple sclerosis

DW Holman, RS Klein… - Biochimica et Biophysica Acta ( …, 2011 - Elsevier
... host defense or inflammation. The expression and display of homeostatic or
inflammatory chemokines therefore critically determine which leukocyte subsets
extravasate and enter the peripheral tissues. Within the CNS, however ...
Cited by 7 - Related articles - All 4 versions

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