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Inflammatory mechanisms in obesity.

MF Gregor… - Annual review of immunology, 2011 - ncbi.nlm.nih.gov
The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes
have elicited interest in the underlying mechanisms of these pathologies. The discovery that
obesity itself results in an inflammatory state in metabolic tissues ushered in a research ...
Cited by 12 - Related articles

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

W Huang, S Ghisletti, K Saijo, M Gandhi, M Aouadi… - Nature, 2011 - nature.com
Toll-like receptors (TLRs) function as initiators of inflammation through their ability to sense
pathogen-associated molecular patterns and products of tissue damage 1, 2 . Transcriptional
activation of many TLR-responsive genes requires an initial de-repression step in which ...
Cited by 4 - Related articles - All 5 versions

Anti-Inflammatory and Antioxidant Properties of a New Arylidene-Thiazolidinedione in Macrophages.

LA Faine, M Rudnicki, FA César… - Current medicinal …, 2011 - ncbi.nlm.nih.gov
Thiazolidinediones (TZDs) are a class of drugs used for treatment of type 2 diabetes.
However, the therapy with currently available TDZs (eg rosiglitazone) is associated with important
side effects, such as edema and weight gain, suggesting that the investigation of ...

Inflammatory Mechanisms in Obesity

G Hotamisligil - Annual Review of Immunology, 2011 - annualreviews.org
The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes
have elicited interest in the underlying mechanisms of these pathologies. The discovery that
obesity itself results in an inflammatory state in metabolic tissues ushered in a research ...
Related articles

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

BZ Qian, J Li, H Zhang, T Kitamura, J Zhang… - Nature, 2011 - nature.com
Macrophages, which are abundant in the tumour microenvironment, enhance malignancy 1 .
At metastatic sites, a distinct population of metastasis-associated macrophages promotes the
extravasation, seeding and persistent growth of tumour cells 2 . Here we define the origin ...
Cited by 6 - Related articles - All 3 versions

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