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K Maeda, J Takano, Y Ikeda, T Fujita… - Clinical Pharmacology …, 2011 - nature.com
Microdosing studies are effective in enabling the early identification of the pharmacokinetic properties
of compounds administered to humans. However, the nonlinearity of the pharmacokinetics between
microdose and therapeutic dose, attributable to the saturation of metabolic enzymes and ...
All 3 versions
SF Noujaim, JA Stuckey… - Cardiovascular …, 2011 - cardiovascres.oxfordjournals.org
Methods and results We used comparative molecular modelling and ligand docking of the
three-dimensional structures of quinidine and chloroquine in the intracellular domain of
Kir2.1. Simulations predicted that chloroquine effectively blocks potassium flow by ...
Cited by 1 - Related articles - All 4 versions
SM Wang, CL Blake, NA Malek, PW Angus… - …, 2011 - espace.library.uq.edu.au
Wang, SM, Blake, CL, Malek, NA, Angus, PW and Ghabrial, H. (2001) Differential inhibition of
human CYP1A1 AND CYP1A2 by quinidine and quinine.. Xenobiotica, 31 11: 757-767. ...
Wang, SM Blake, CL Malek, NA Angus, PW Ghabrial, H. ... Differential inhibition of ...
Cached - All 3 versions
GE O'Hara, F Philippon, M Gilbert… - The Journal of …, 2011 - jcp.sagepub.com
Propafenone and its 5-hydroxy metabolite exhibit different electrophysiological properties. Objectives
of the CAQ-PAF study were (1) to develop a strategy favoring propafenone instead of 5-hydroxypropafenone
in plasma following oral administration of propafenone and (2) to evaluate the potential of ...
Related articles - All 3 versions
I Sziráki, F Erdő, E Beéry, PM Molnár… - Journal of …, 2011 - jbx.sagepub.com
1solvo biotechnology, szeged, hungary 2department of biochemistry, faculty of Medicine, university
of szeged, hungary 3institute of biophysics, biological research Center, szeged, hungary 4department
of Medical Chemistry, faculty of Medicine, university of szeged, szeged, hungary 5trans- ...

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