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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

[HTML] from nih.govPJ Stephens, CD Greenman, B Fu, F Yang… - Cell, 2011 - Elsevier
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements,
conventionally thought to accumulate gradually over time. Using next-generation
sequencing, we characterize a phenomenon, which we term chromothripsis, whereby ...
Cited by 21 - Related articles - All 7 versions

Global health and climate change: moving from denial and catastrophic fatalism to positive action

A Costello, M Maslin… - … of the Royal …, 2011 - rsta.royalsocietypublishing.org
The health effects of climate change have had relatively little attention from climate scientists
and governments. Climate change will be a major threat to population health in the current century
through its potential effects on communicable disease, heat stress, food and water ...
Cited by 1 - Related articles - All 3 versions

Catastrophic Antiphospholipid Syndrome

MJ Cuadrado, G Sanna, ML Bertolaccini… - Autoimmune …, 2011 - Springer
Abstract Antiphospholipid syndrome (APS) is characterized by the development of arterial
and/or venous thrombosis and/or pregnancy morbidity in the presence of antiphos- pholipid antibodies
(aPL) anticardiolipin (aCL), anti-b2-glycoprotein I (anti-b2GPI), and lupus anticoagulant ...
Related articles - All 2 versions

Catastrophic Drought in the Afro-Asian Monsoon Region During Heinrich Event 1

JC Stager, DB Ryves, BM Chase… - Science, 2011 - sciencemag.org
... 331 no. 6022 pp. 1299-1302 DOI: 10.1126/science.1198322. Report. Catastrophic Drought in
the Afro-Asian Monsoon Region During Heinrich Event 1. ... Whatever its exact cause, such a
catastrophic drought would have had powerful effects on Paleolithic cultures. ...
Cited by 1 - Related articles - All 5 versions

Losing control: Cancer's catastrophic transition

I Rajapakse, D Scalzo… - Nucleus, 2011 - es.landesbioscience.com
Adaptability and "emergent" properties are the dominant characteristics of complex systems,
whether naturally occurring or engineered. Structurally, a complex system might be made up
of a large number of simpler components, or it might be formed from hierarchies of ...
Cached - All 4 versions

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