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Antipruritic Effects of TRPV1 Antagonist in Murine Atopic Dermatitis and Itching Models

JW Yun, JA Seo, WH Jang, HJ Koh… - Journal of Investigative …, 2011 - nature.com
TO THE EDITORTransient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation
channel widely expressed in skin tissues, including keratinocytes and peripheral sensory nerve
fibers (C and Aδ). Activated by noxious heat, capsaicin, or endogenous inflammatory ...
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A Randomized, Double-Blind, Vehicle-Controlled Crossover Study to Determine the Anti-Pruritic Efficacy, Safety and Local Dermal Tolerability of a Topical …

JL Herzog, JA Solomon, Z Draelos… - Journal of drugs in …, 2011 - ncbi.nlm.nih.gov
Objective: To investigate the efficacy, safety and tolerability of topical nalmefene (SRD174), a
long acting opioid antagonist for the management of pruritus associated with atopic dermatitis
(AD). Design: Double-blind, vehicle-controlled, randomized, cross-over trial. Setting: ...

Preparation and Quality Control of Compound Dyclonine Menthol Antipruritic Emollients Lotion

T LI, C LI, K ZHANG, L FENG, Y LUO… - China Pharmacy, 2011 - en.cnki.com.cn
OBJECTIVE:To prepare Compound dyclonine menthol antipruritic emollients lotion and to establish
its quality control method. METHODS:Lotion for external use was prepared using dyclonine and
menthol as main component. HPLC method was used to determine the content of ...
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[HTML] Pharmacological and neuroanatomical analysis of GNTI-induced repetitive behavior in mice

[HTML] from umi.comS Inan - 2011 - gradworks.umi.com
... Our c-fos results suggest that the preclinical antipruritic activity of nalfurafine occurs
at the spinal level. Moreover, our results reinforce the need to evaluate nalfurafine as
a potentially useful antipruritic in human conditions involving itch. ...
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Determination of Chlorogenic acid in Gynecological Antipruritic Capsule by HPLC

C Yeqing - China Pharmaceuticals, 2011 - en.cnki.com.cn
Objective To establish the determination method of chlorogenic acid in Gynecological Antipruritic
Capsule.Methods The XBridgeTM-C18 column(150 mm×4.6 mm,5 μm) was used with
methanol-0.1% phosphoric acid(15 ∶85) as the mobile phase,the flow rate was 1.0 ...
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