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… -cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia

FR Schuster, B Hubner, M Führer… - Blood Cancer …, 2011 - nature.com
One of the major obstacles of immunosuppressive therapy (IST) in children with severe aplastic
anemia (SAA) comes from the often months-long unpredictability of bone-marrow (BM)
recovery. In this prospective study in children with newly diagnosed very severe AA ...
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Late effects among pediatric patients followed for nearly four decades after transplantation for severe aplastic anemia.

JE Sanders, AE Woolfrey, PA Carpenter, BE Storer… - Blood, 2011 - ncbi.nlm.nih.gov
Aplastic anemia (AA), a potentially fatal disease, may be cured with marrow transplantation. Survival
in pediatric patients has been excellent early after transplant, but only limited data are available
regarding late effects. This study evaluates late effects among 152 patients followed 1-38 ( ...

Horse versus Rabbit Antithymocyte Globulin in Acquired Aplastic Anemia

P Scheinberg, O Nunez, B Weinstein… - New England Journal …, 2011 - nejm.org
A large, unexpected difference was observed in the rate of hematologic response at 6 months
in favor of horse ATG (68%; 95% confidence interval [CI], 56 to 80) as compared with rabbit ATG
(37%; 95% CI, 24 to 49; P<0.001). Overall survival at 3 years also differed, with a survival ...

Decreased infection-related mortality and improved survival in severe aplastic anemia in the past two decades

JM Valdez, P Scheinberg, O Nunez… - Clinical Infectious …, 2011 - cid.oxfordjournals.org
Results. During the past 2 decades, infection-related mortality decreased from 37% in group
1 to 11% in group 3 (P<.001), and the frequency of IFIs decreased from 49% in group 1 to 8%
in group 3 (P<.001). Overall 5-year survival for all patients (n = 420) increased from 64% ...
Cited by 3 - Related articles - All 4 versions

Environmental lead exposure as a risk for childhood aplastic anemia.

M Ahamed, MJ Akhtar, S Verma, A Kumar… - Bioscience …, 2011 - ncbi.nlm.nih.gov
Concern about environmental lead exposure as a significant public health threat has increased
as evidence has accumulated regarding adverse health effects at successively lower levels.
Aplastic anemia is a hematological disorder of unknown etiology with a high lethality rate. ...

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