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Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

G Ragupathi, JR Gardner… - Expert Review of …, 2011 - ingentaconnect.com
Molecular identification of human tumor anti- gens found to be immunogenic in humans after
natural exposure or treatment with cancer vac- cines has resulted in a wide array of increasingly
focused vaccines designed to further augment their immunogenicity. However, as ...
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Preclinical evaluation of the saponin derivative GPI-0100 as an immunostimulating and dose-sparing adjuvant for pandemic influenza vaccines

H Liu, L Bungener, W ter Veer, BA Coller… - Vaccine, 2011 - Elsevier
With the current global influenza vaccine production capacity the large demand for vaccines
in case of a pandemic can only be fulfilled when antigen dose sparing strategies are
employed. Here we used a murine challenge model to evaluate the potential of GPI-0100, ...
Cited by 1 - Related articles - All 3 versions

Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng

TD Kim, JY Han, GH Huh… - Plant and Cell Physiology, 2011 - Jpn Soc Plant Physiol
Squalene synthase (SQS) catalyzes the biosynthesis of squalene by condensing two molecules
of farnesyl pyrophosphate (FPP), a key precursor in sterol and triterpene biosynthesis.
Previously, we reported that PgSS1 overexpression results in the enhanced biosynthesis ...
Cited by 1 - Related articles - All 5 versions

Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1

J Maj, JW Morzycki, LR rov … - Journal of medicinal …, 2011 - ACS Publications
“Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are
posted online prior to technical editing, formatting for publication and author proofing. The American
Chemical Society provides “Just Accepted” as a free service to the research community to ...
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Vaccine compositions comprising virosomes and a saponin adjuvant

B Coller, V Henderickx… - EP Patent 2,269,638, 2011 - freepatentsonline.com
The invention provides virosome preparations from an enveloped virus, in particular from influenza
virus, containing an antigen from said virus, and a saponin adjuvant. In particular the invention
provides a virosome preparation from influenza virus containing an influenza antigen a ...
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