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Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKC [delta] in cell culture and animal models of Parkinson's disease

C Latchoumycandane, V Anantharam, H Jin… - Toxicology and Applied …, 2011 - Elsevier
The neurotoxicant 6-hydroxydopamine (6-OHDA) is used to investigate the cellular and molecular
mechanisms underlying selective degeneration of dopaminergic neurons in Parkinson's disease
(PD). Oxidative stress and caspase activation contribute to the 6-OHDA-induced apoptotic ...

Is the PentaBDE Replacement, Tris (1, 3-dichloro-2-propyl) Phosphate (TDCPP), a Developmental Neurotoxicant? Studies in PC12 Cells

LV Dishaw, CM Powers, IT Ryde… - Toxicology and Applied …, 2011 - Elsevier
Organophosphate flame retardants (OPFRs) are used as replacements for the commercial PentaBDE
mixture that was phased out in 2004. OPFRs are ubiquitous in the environment and detected
at high concentrations in residential dust, suggesting widespread human exposure. ...
Cited by 1 - Related articles - All 2 versions

Aroclor-1254, a developmental neurotoxicant, alters energy metabolism-and intracellular signaling-associated protein networks in rat cerebellum and hippocampus

PRS Kodavanti, C Osorio, JE Royland… - Toxicology and Applied …, 2011 - Elsevier
The vast literature on the mode of action of polychlorinated biphenyls (PCBs) indicates that PCBs
are a unique model for understanding the mechanisms of toxicity of environmental mixtures of
persistent chemicals. PCBs have been shown to adversely affect psychomotor function ...

Exposure to an Environmental Neurotoxicant Hastens the Onset of Amyotrophic Lateral Sclerosis-Like Phenotype in Human Cu2+/Zn2+ Superoxide Dismutase 1 …

FO Johnson, Y Yuan, RK Hajela, A Chitrakar… - … of Pharmacology and …, 2011 - ASPET
Preliminary reports of portions of this project were presented previously: Johnson FO, Atchison
WD, and Chitrakar A. (2010) Chronic methylmercury exposure potentiates [Zn 2+ ] 1 in motor
neurons of hSOD1 mice, at the Annual Meeting of the Society of Toxicology; 2010 March ...

Exposure to an Environmental Neurotoxicant Hastens the Onset of ALS Phenotype in hSOD1G93A Mice: Glutamate-Mediated Excitotoxicity

FO Johnson, Y Yuan, RK Hajela, DM Parsell… - … of Pharmacology and …, 2011 - ASPET
Page 1. JPET 174466 1 Exposure to an Environmental Neurotoxicant Hastens the Onset of
ALS-Like Phenotype in hSOD1G93A Mice: Glutamate-Mediated Excitotoxicity ... genetically-
susceptible organism by exposure to low concentrations of an environmental neurotoxicant. ...
Related articles - All 2 versions

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