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A Phase 1 Dose-Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer

DS Hong, R Kurzrock, Y Oh, JJ Wheler… - Clinical Cancer …, 2011 - AACR
... Fifteen patients had progressive disease, and seven patients achieved stable disease
(minimum of 6 weeks) as best ... and a lowest no observed-adverse-effect level (NOAEL) for
LY2275796 was defined at 5 mg/kg in mice and 2 mg/kg in monkeys. ...
Cited by 1

A Brief survey of First-in-human studies

D Wexler… - The Journal of Clinical Pharmacology, 2011 - jcp.sagepub.com
... I). In designating the dose associated with the no observable adverse effect level (NOAEL),
investigators ... Observed mean (standard deviation) vs predicted values for human oral clearance
(L/h ... are compared with both relative toxicity profiles and the minimum anticipated biologic ...
Related articles - All 3 versions

Expression of heat shock protein 70 in Cirrhinus mrigala (Ham.) exposed to thermal variations

[PDF] from icar.org.inP Das, SK Manna, SA Mastan… - Indian Journal of …, 2011 - epubs.icar.org.in
... Under adverse environmental conditions, synthesis of this protein (HSP-70) increases and they
act to repair and ... In the present study, it has been observed that the concentration of HSP 70 in
the ... the changed metabolism with the physical stress are minimum in these two organs. ...
Related articles - All 2 versions

Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer

D Rathkopf, G Liu, MA Carducci… - Clinical Cancer …, 2011 - AACR
... The minimum efficacious exposure of the compound of 12.7 μmol/L h (AUC 0–24 ) was projected
to occur in humans in the range of 60–80 mg/d ... Data points are observed data and the solid lines
are the results of regression analysis. NOAEL, no observable adverse effect level. ...
Cited by 3 - Related articles - All 3 versions

Safety assessment of a solid lipid curcumin particle preparation: Acute and subchronic toxicity studies

P Dadhaniya, C Patel, J Muchhara… - Food and Chemical …, 2011 - Elsevier
... Analyses were conducted using two-tailed Student's “t” test for minimum significance levels of 5%,
comparing Group I to Groups II, III and IV, and Group V to VI by sex. ... Similarly, in the recovery group
also no adverse effects of the curcumin preparation were observed. ...
All 2 versions

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