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Cardiovascular Event Reduction and Adverse Events Among Subjects Attaining Low-Density Lipoprotein Cholesterol< 50 mg/dl With Rosuvastatin:: The JUPITER …

[PDF] from goodsamhosp.orgJ Hsia, JG MacFadyen, J Monyak… - Journal of the American …, 2011 - Elsevier
During a median follow-up of 2 years (range up to 5 years), rates of the primary trial endpoint
were 1.18, 0.86, and 0.44 per 100 person-years in the placebo group (n = 8,150) and rosuvastatin
groups without LDL-C <50 mg/dl (n = 4,000) or with LDL-C <50 mg/dl (n = 4,154), ...
Cited by 2 - Related articles - All 6 versions

Dose-Dependent Modulation of Tissue Factor Protein and Procoagulant Activity in Human Monocyte-Derived Macrophages by Oxidized Low Density Lipoprotein.

SR Meisel, XP Xu, TS Edgington… - … of atherosclerosis and …, 2011 - ncbi.nlm.nih.gov
Aim: Oxidized low-density lipoprotein (oxLDL) interacts with macrophages and is implicated
in atherogenesis. Macrophages are also the major source within the atherosclerotic plaque of
tissue factor (TF), the membrane-bound glycoprotein receptor that triggers the ...

… Element-Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

T Karasawa, A Takahashi, R Saito… - … and Vascular Biology, 2011 - Am Heart Assoc
Methods and Results— Transgenic mice that overexpress SREBP-1c in the liver and
SREBP-1-deficient mice were crossed with low-density lipoprotein receptor (LDLR)–deficient
mice, and the plasma lipids and atherosclerosis were analyzed. Hepatic SREBP-1c ...
All 3 versions

Oxidized Low-Density Lipoprotein Activates p66Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase …

Y Shi, F Cosentino, GG Camici… - … and Vascular Biology, 2011 - Am Heart Assoc
Methods and Results—Incubation of human aortic endothelial cells with oxLDL led to phosphorylation
of p66 Shc at Ser36. Inhibition of lectin-like oxLDL receptor-1 prevented p66 Shc
phosphorylation, confirming that this effect is mediated by lectin-like oxLDL receptor-1. ...

Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ …

VR Babaev, RP Runner, D Fan… - … and Vascular Biology, 2011 - Am Heart Assoc
Methods and Results— We transplanted wild-type (WT), Mal1 –/– , or aP2 –/– bone marrow into
low-density lipoprotein receptor–null (LDLR –/– ) mice and fed them a Western diet for 8
weeks. Mal1 –/– LDLR –/– mice had significantly reduced (36%) atherosclerosis in the ...
Related articles - All 3 versions

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