the area under the plasma concentration-time curve 是什么意思，中文意思 | 血浓时间曲线下面积英文怎么说医学英语中英文词汇翻译

Assessment of pharmacologic area under the curve when baselines are variable

[PDF] from jeremyscheff.comJD Scheff, RR Almon, DC DuBois, WJ Jusko… - Pharmaceutical …, 2011 - Springer
... pharmacogenomics INTRODUCTION In pharmacology, the area under the plot of plasma
concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives
insight into the extent of exposure to a drug and its clearance rate from the body. ...
Cited by 3 - Related articles - All 4 versions

… 3-5 CHRONIC KIDNEY DISEASE (CKD) PATIENTS? PREDICTION OF GLOMERULAR FILTRATION RATE FROM SERUM CONCENTRATION OF CYSTATIN C: …

D Bolignano, L Zanoli, S Rastelli… - NDT …, 2011 - ndtplus.oxfordjournals.org
... methods are difficult to use in daily practice and the estimated GFR by formulas incorporating
plasma creatinine (Pcr ... PREDICTION OF GLOMERULAR FILTRATION RATE FROM SERUM
CONCENTRATION OF CYSTATIN C: COMPARISON OF TWO ANALYTICAL METHODS. ...

Plasma/skin distribution of ketoprofen (KTP) in rabbit following IV infusion administrations

J Patel - 2011 - gradworks.umi.com
... administration. Therefore, the area under the skin concentration curve (AUCskin ) is
directly proportional to the area under the plasma concentration (AUCplasma ). To test
this hypothesis Ketoprofen (KTP) was selected as model drug. ...
Cached

Itraconazole, a p-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren

T Tapaninen, JT Backman, KJ Kurkinen… - The Journal of …, 2011 - jcp.sagepub.com
... Itraconazole raised the peak plasma aliskiren concentration 5.8-fold (range, 1.1- to 24.3-fold;
P < .001) and the area under the plasma aliskiren concentration-time curve 6.5-fold (range, 2.6-
to 20.5-fold; P < .001) but had no significant effect on aliskiren elimination half-life. ...
Cited by 6 - Related articles - All 5 versions

Postprandial Lipemia in Elderly Involves Increased Incorporation of Ingested Fat in Plasma Free Fatty Acids and Small (Sf 20-400) Triglyceride-rich Lipoproteins

GM Puga, C Meyer, S Everman… - American Journal of …, 2011 - Am Physiological Soc
... As expected, the 32 area under the curve of postprandial plasma TG concentrations was
larger in the elderly compared to the young 33 ... in elderly. Plasma apo B-100 concentration
was higher, whereas the rate of oxidation of the ingested lipid was 38 ...

Assessment of pharmacologic area under the curve when baselines are variable

[PDF] from jeremyscheff.comJD Scheff, RR Almon, DC DuBois, WJ Jusko… - Pharmaceutical …, 2011 - Springer
... pharmacogenomics INTRODUCTION In pharmacology, the area under the plot of plasma
concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives
insight into the extent of exposure to a drug and its clearance rate from the body. ...
Cited by 3 - Related articles - All 4 versions

… 3-5 CHRONIC KIDNEY DISEASE (CKD) PATIENTS? PREDICTION OF GLOMERULAR FILTRATION RATE FROM SERUM CONCENTRATION OF CYSTATIN C: …

D Bolignano, L Zanoli, S Rastelli… - NDT …, 2011 - ndtplus.oxfordjournals.org
... methods are difficult to use in daily practice and the estimated GFR by formulas incorporating
plasma creatinine (Pcr ... PREDICTION OF GLOMERULAR FILTRATION RATE FROM SERUM
CONCENTRATION OF CYSTATIN C: COMPARISON OF TWO ANALYTICAL METHODS. ...

Plasma/skin distribution of ketoprofen (KTP) in rabbit following IV infusion administrations

J Patel - 2011 - gradworks.umi.com
... administration. Therefore, the area under the skin concentration curve (AUCskin ) is
directly proportional to the area under the plasma concentration (AUCplasma ). To test
this hypothesis Ketoprofen (KTP) was selected as model drug. ...
Cached

Itraconazole, a p-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren

T Tapaninen, JT Backman, KJ Kurkinen… - The Journal of …, 2011 - jcp.sagepub.com
... Itraconazole raised the peak plasma aliskiren concentration 5.8-fold (range, 1.1- to 24.3-fold;
P < .001) and the area under the plasma aliskiren concentration-time curve 6.5-fold (range, 2.6-
to 20.5-fold; P < .001) but had no significant effect on aliskiren elimination half-life. ...
Cited by 6 - Related articles - All 5 versions

Postprandial Lipemia in Elderly Involves Increased Incorporation of Ingested Fat in Plasma Free Fatty Acids and Small (Sf 20-400) Triglyceride-rich Lipoproteins

GM Puga, C Meyer, S Everman… - American Journal of …, 2011 - Am Physiological Soc
... As expected, the 32 area under the curve of postprandial plasma TG concentrations was
larger in the elderly compared to the young 33 ... in elderly. Plasma apo B-100 concentration
was higher, whereas the rate of oxidation of the ingested lipid was 38 ...

Iniparib plus chemotherapy in metastatic triple-negative breast cancer

[PDF] from medpagetoday.comJ O'Shaughnessy, C Osborne… - … England Journal of …, 2011 - Mass Medical Soc
... A total of 123 patients were randomly assigned to receive gemcitabine (1000 mg per square
meter of body-surface area) and carboplatin (at a dose equivalent to an area under the
concentration–time curve of 2) on days 1 and 8 — with or without iniparib (at a dose of 5.6 mg ...
Cited by 58 - Related articles - All 7 versions

Numerical analysis of dynamic failure process of inhomogeneous medium based on large diameter SHPB test [J]

Y ZUO, C TANG, S LI, W ZHU… - Rock and Soil Mechanics, 2011 - en.cnki.com.cn
... the dynamic failure process and dynamic properties of inhomogeneous medium in large diameter
split Hopkinson pressure bar(SHPB);the influence of waveform loaded to incidence bar and
inhomogeneous medium on test results including stress-time curve,strain-time curve ...
Cited by 25 - Related articles - Cached

Effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide

C Kapitza, M Zdravkovic, E Zijlstra… - The Journal of …, 2011 - jcp.sagepub.com
... Area under the plasma liraglutide concentration–time curve from time zero to time t (AUC 0-t )
was calculated by the trapezoidal rule. Maximum liraglutide concentration (C max ) and time
to C max (t max ) were obtained directly from the concentration–time curve. ...
Cited by 10 - Related articles - All 3 versions

Itraconazole, a p-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren

T Tapaninen, JT Backman, KJ Kurkinen… - The Journal of …, 2011 - jcp.sagepub.com
... Itraconazole raised the peak plasma aliskiren concentration 5.8-fold (range, 1.1- to 24.3-fold;
P < .001) and the area under the plasma aliskiren concentration-time curve 6.5-fold (range, 2.6-
to 20.5-fold; P < .001) but had no significant effect on aliskiren elimination half-life. ...
Cited by 6 - Related articles - All 5 versions

Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated …

[HTML] from jcojournal.orgE Van Cutsem, E Bajetta, J Valle… - Journal of Clinical …, 2011 - jcojournal.org
... Plasma PTK/ZK concentrations were measured by high-performance liquid
chromatography with an ultraviolet detector. PK variables evaluated were maximum
concentration, area under the concentration–time curve, and trough level. ...
Cited by 2 - Related articles - All 5 versions

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