systemic clearance 是什么意思，中文意思 | 总清除率英文怎么说医学英语中英文词汇翻译

The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5

F Xie, X Zhou, MB Genter, M Behr, J Gu… - Drug Metabolism and …, 2011 - ASPET
... We showed that the loss of CYP2A5 expression did not alter systemic clearance of
MMZ (at 50 mg/kg, ip); but it did significantly decrease the rates of MMZ metabolism
in the OM, whereas FMO expression in the OM was not reduced. ...
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In Vivo CYP3A Activity Is Significantly Lower in Cyclosporine-Treated as Compared With Tacrolimus-Treated Renal Allograft Recipients

H de Jonge, H de Loor, K Verbeke… - Clinical Pharmacology …, 2011 - nature.com
... 4,5 The oral bioavailability and systemic clearance of these drugs are controlled mainly by the
cytochrome P450 isoenzymes CYP3A4 and 3A5 and the drug transporter P-glycoprotein, which
are expressed in enterocytes (affecting oral bioavailability) and hepatocytes (affecting ...

Opposite Effect of Diabetes Mellitus Induced by Streptozotocin on Oral and Intravenous Pharmacokinetics of Verapamil in Rats

N Hu, S Xie, L Liu, X Wang, X Pan, G Chen… - Drug Metabolism and …, 2011 - ASPET
... To investigate whether higher oral exposure of verapamil in plasma of diabetic rats resulted from
a decrease in systemic clearance, the pharmacokinetics of verapamil (Fig. 1C) were studied in
diabetic and control rats after intravenous administration of verapamil (1 mg/kg). ...
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Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients With Atrial Fibrillation or Atrial Flutter

ZL Mao, RW Townsend, C Gao… - The Journal of …, 2011 - jcp.sagepub.com
... Median systemic clearance was 0.35 L/h/kg (or 28 L/h for an 80-kg patient), with intersub- ject
variability estimated to be 40%. Clearance was sig- nificantly influenced by CYP2D6 genotype,
age, serum creatinine concentration, and subject status (patient vs volunteer). ...
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… arthritis: data from the british society for rheumatology biologics registerDefective clearance of apoptotic neutrophils in juvenile systemic lupus erythematosusIS 3 …

SV Ball, JL Maxwell, MK Cruikshank… - …, 2011 - Br Soc Rheumatology
Background: Transition from primary to secondary school can be worrying for all young
people. The social aspects of the move have been found to be more important to young people
than learning issues [1]. There have however been no studies in the rheumatology ...
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