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Prediction of Oral Pharmacokinetics of cMet Kinase Inhibitors in Humans: Physiologically Based Pharmacokinetic Model Versus Traditional One-Compartment Model

S Yamazaki, J Skaptason, D Romero… - Drug Metabolism and …, 2011 - ASPET
The objective of this study was to assess the physiologically based pharmacokinetic (PBPK)
model for predicting plasma concentration-time profiles of orally available cMet kinase
inhibitors, (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4- ...
Cited by 2 - Related articles - All 4 versions

Limitations of the permeability-limited compartment model in estimating vascular permeability and interstitial volume fraction in DCE-MRI

G Correia Carreira, O Gemeinhardt… - Magnetic Resonance …, 2011 - Elsevier
... This work systematically examines the widely used permeability-surface-limited
one-compartment model to determine the reliability of the parameters obtained by
comparing them with their actual values. A computer simulation ...
Related articles - All 3 versions

Bayesian population pharmacokinetic analysis of sirolimus

C Dansirikul, LE Friberg… - … Approach Group in …, 2011 - espace.library.uq.edu.au
... When a one-compartment model was applied, information was gained from the data for the value
of apparent clearance (CL/F = 18.5 L/h), and apparent volume of distribution (V/F = 1406 L) but
no information was gained about the absorption rate constant (ka). ...
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[PDF] Compartment Model for Controlling Infectious Livestock Disease: Cost-Effective Control Strategies for Johne's Disease In Dairy Herds

[PDF] from umn.eduJ Cho, L Tauer, Y Schukken… - … Meeting, July 24-26 …, 2011 - ageconsearch.umn.edu
... herds had at least one MAP-infected cow in Canada and the US, respectively. Given this Page
5. 4 ... ECONOMIC MODEL FOR INFECTIOUS ANIMAL DISEASE CONTROL Animals within a
herd or region can be grouped into different compartment i∈I={1,…,I} ...
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Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia

Q Lu, JJ Rouby, PF Laterre… - Journal of …, 2011 - Br Soc Antimicrob Chemo
... The contribution of each dose after infusion stop was calculated as shown in Equation 2 for the
one-compartment model and Equation 3 for the two-compartment model: (2) (3) where C infusion
(infusion stop) corresponds to C infusion (t) at infusion stop (see Eq. ...
Cited by 1 - Related articles - All 5 versions

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