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Time-oriented experimental design method to optimize hydrophilic matrix formulations with gelation kinetics and drug release profiles

S Shin, DH Choi, NKV Truong, NA Kim… - International journal of …, 2011 - Elsevier
A new experimental design methodology was developed by integrating the response surface
methodology and the time series modeling. The major purposes were to identify significant factors
in determining swelling and release rate from matrix tablets and their relative factor levels ...
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Optimization of extended-release hydrophilic matrix tablets by support vector regression

N Al-Zoubi, K Kachrimanis… - Drug Development …, 2011 - informahealthcare.com
Background: In this work, support vector regression (SVR) was applied to the optimization of
extended release from swellable hydrophilic pentoxifylline matrix-tablets and compared to multiple
linear regression (MLR). Methods: Binary mixtures comprising ethylcellulose and sodium ...
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Comparison of the characteristics of several polymer materials used in hydrophilic matrix tablets].

SF Nie, H Liu, YL Liu… - Yao xue xue bao= Acta …, 2011 - ncbi.nlm.nih.gov
Pure and drug hydrophilic matrix tablets were prepared by direct compression method with theophylline
as a model drug. The characteristics of four hydrophilic matrix polymers, hydroxypropylmethylcellulose
(HPMC), polyethylene oxide (PEO), sodium alginate (NaAlg) and xanthan gum (XG), ...
All 2 versions

Evaluation of hydrophilic matrix tablets based on Carbopol® 971P and low-viscosity sodium alginate for pH-independent controlled drug release

NM Al-Zoubi, HS AlKhatib… - Drug Development and …, 2011 - informahealthcare.com
Background: The aim of this study was to evaluate matrix tablets containing different ratios of
Carbopol ® 971P (CP) to low-viscosity sodium alginate (SA) and assess their suitability for
pH-independent controlled drug release. Methods: Two processing methods (physical ...
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[HTML] Development of an extended release naproxen sodium matrix tablet and evaluation of the effects of various fillers and additives on drug release kinetics

[HTML] from umi.comMR Patel - 2011 - gradworks.umi.com
... Abstract: Hydroxypropyl methyl cellulose (HPMC) has been used as a hydrophilic matrix
system in extended release formulations. Limited work has been performed and published
on hydroxypropyl cellulose (HPC) as a hydrophilic matrix system. ...
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