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[HTML] Frontiers: Guggulsterone-Mediated Enhancement of Radiosensitivity in Human Tumor Cell Lines

[HTML] from frontiersin.orgR Choudhuri, W DeGraff, J Gamson… - Frontiers in Radiation …, 2011 - frontiersin.org
Home; About; Submit; Advertise & PR. Register; Login. Science: Genetics: Applied
Genetic Epidemiology; Behavioral and Psychiatric Genetics; Bioinformatics and
Computational Biology; Cancer Genetics; Epigenomics; Evolutionary ...
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Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

SS Devgan, O Sanal, C Doil, K Nakamura… - Cell Death & …, 2011 - nature.com
Maintaining genomic integrity is critical to avoid life-threatening disorders, such as premature
aging, neurodegeneration and cancer. A multiprotein cascade operates at sites of DNA
double-strand breaks (DSBs) to recognize, signal and repair damage. RNF168 ...
Cited by 5 - Related articles - All 3 versions

Homozygous deficiency of ubiquitin ligase RNF168 defines a radiosensitivity syndrome mimicking ataxia-telangiectasia

[PDF] from cnrs.frJ Bartek, S Devgan, C Doil, K Nakamura… - 2011 - peer.ccsd.cnrs.fr
Page 1. 1 Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics
the radiosensitivity syndrome of ataxia-telangiectasia ... consistent with the observed defective
DNA damage checkpoints/repair and pronounced radiosensitivity. ...

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

YV Wang, M Leblanc, N Fox, JH Mao… - Genes & …, 2011 - genesdev.cshlp.org
Cell cycle regulation in hematopoietic stem cells (HSCs) is tightly controlled during homeostasis
and in response to extrinsic stress. p53, a well-known tumor suppressor and transducer of diverse
stress signals, has been implicated in maintaining HSC quiescence and self-renewal. ...
Related articles - All 2 versions

The dominant negative mutant Artemis enhances tumor cell radiosensitivity.

H Liu, X Sun, S Zhang, W Ge, Y Zhu… - … and oncology: journal …, 2011 - ncbi.nlm.nih.gov
BACKGROUND: Tumor radioresistance often leads to treatment failure during radiotherapy.
New strategies like developing radiosensitizer are clinically important. Intervention with DNA
double-strand break repair is an effective way to modulate tumor cell radiosensitivity. This ...
All 2 versions

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