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Blockade of TSP1-Dependent TGF-[beta] Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy

A Lu, M Miao, TR Schoeb, A Agarwal… - The American Journal of …, 2011 - Elsevier
Transforming growth factor-β (TGF-β) is key in the pathogenesis of diabetic nephropathy. Thrombospondin
1 (TSP1) expression is increased in diabetes, and TSP1 regulates latent TGF-β activation in
vitro and in diabetic animal models. Herein, we investigate the effect of blockade of TSP1- ...
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CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier
We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation
of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF
activity and expression of Wnt targets. This is coincident with decreased phosphorylation ...
Cited by 3 - Related articles - All 3 versions

Postprandial hyperinsulinemia is universal in non‐diabetic patients with nonalcoholic fatty liver disease

J Manchanayake, S Chitturi, C Nolan… - Journal of …, 2011 - Wiley Online Library
Background and Aims: Despite strong associations between non-alcoholic fatty liver disease
(NAFLD) and type 2 diabetes (T2D), it is unclear which patients need oral glucose tolerance
testing (OGTT). Relationships between hyperglycemia, postprandial hyperinsulinemia ...
Cited by 1 - Related articles - All 4 versions

[PDF] Anti-diabetic effect of Rubus ellipticus fruit extracts in alloxan induced diabetic rats

[PDF] from journalofdiabetology.orgUS Sharma… - Journal of Diabetology, 2011 - journalofdiabetology.org
Alloxan (2, 4, 5, 6-tetraoxypyrimidine; 2, 4, 5, 6-pyrimidinetetrone) is a toxic glucose
analogue, which selectively destroys insulin-producing pancreatic β-cells and causes a
non-insulin-dependent diabetes mellitus (NIDDM), when administered to animal species. ...
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Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats

O Chan, S Paranjape, D Czyzyk, A Horblitt… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Impaired glucose counterregulation during hypoglycemia is well documented in
patients with type 1 diabetes; however, the molecular mechanisms underlying this defect remain
uncertain. We reported that the inhibitory neurotransmitter γ-aminobutyric acid (GABA), in ...
All 3 versions

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