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VEGF Binding to Neuropilin-1 (NRP1) is Essential for VEGF Stimulation of Endothelial Cell Migration, Complex Formation between NRP1 and VEGFR2 and Signalling …

B Herzog, C Pellet-Many, G Britton… - Molecular Biology of …, 2011 - Am Soc Cell Biol
In endothelial cells, Neuropilin-1 (NRP1) binds VEGF-A and is thought to act as a coreceptor
for KDR by associating with KDR and enhancing VEGF signalling. Here we report mutations
in the NRP1 b1 domain (Y297A and D320A), which result in complete loss of VEGF ...
All 3 versions

… , a Dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF …

E Allen, IB Walters… - Clinical Cancer Research, 2011 - AACR
Experimental Design: An anti-VEGFR2 monoclonal antibody (DC101), an inhibitor of FGF signaling
(FGF ligand trap), sorafenib, and brivanib were comparatively evaluated in first-line monotherapy
in short and longer term fixed endpoint intervention trials in the RIP-Tag2 mouse model of ...
Cited by 2

Brivanib, an FGF/VEGF inhibitor, is differentially active 1st vs. 2nd line against mouse PNET tumors developing evasive/adaptive resistance to VEGF inhibition

E Allen, I Walters… - Clinical Cancer Research, 2011 - AACR
Page 1. Published OnlineFirst May 27, 2011. Clin Cancer Res Elizabeth Allen, Ian Walters and
Douglas Hanahan evasive/adaptive resistance to VEGF inhibition 2nd line against mouse PNET
tumors developing Brivanib, an FGF/VEGF inhibitor, is differentially active 1st vs. ...
Related articles - All 2 versions

Vascular Endothelial Growth Factor (VEGF) Attenuates Hyperoxia Via Neuropilin-1 (nrp)-Protein Kinase C (pkc) Dependent Pathway In Explanted Embryonic Lung

AE Esquibies, A Bazzy-Asaad… - American Journal of …, 2011 - Am Thoracic Soc
Yale University, New Haven, CT, Yale School of Medicine, New Haven 1 2 ... Corresponding
author's email: americo.esquibies@yale.edu ... VEGF is regulated by oxygen and plays an important
role in vascular development and epithelial cell morphogenesis. During hyperoxia, VEGF ...
All 3 versions

Inhibition Of VEGFr-2 Induces Apoptosis And VEGF Protein Expression In Human Pulmonary Microvascular Endothelial Cells

L Farkas, M Greve, D Farkas… - American Journal of …, 2011 - Am Thoracic Soc
Pulmonary arterial hypertension (PAH) is a deadly disease with poor prognosis, histologically
characterized by Introduction: angioproliferative lesions with hyperproliferative, apoptosis-resistant
endothelial cells (ECs). Our group has previously shown that inhibition of vascular ...
All 3 versions

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