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Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

AG Schepers, R Vries, M Van Den Born… - The EMBO …, 2011 - nature.com
Somatic cells have been proposed to be limited in the number of cell divisions they can
undergo. This is thought to be a mechanism by which stem cells retain their integrity preventing
disease. However, we have recently discovered intestinal crypt stem cells that persist for ...
Cited by 5 - Related articles - All 4 versions

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

[HTML] from pnas.orgRK Montgomery, DL Carlone… - Proceedings of the …, 2011 - National Acad Sciences
The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5 + ) intestinal stem
cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in
the intestine to protect the genome from accumulating deleterious mutations and to allow ...
Cited by 10 - Related articles - All 4 versions

Telomerase and Retrotransposons: Reverse Transcriptases That Shaped Genomes Special Feature Sackler Colloquium: Architecture of human telomerase RNA.

Q Zhang, NK Kim… - … of the National Academy of Sciences …, 2011 - ncbi.nlm.nih.gov
Telomerase is a unique reverse transcriptase that catalyzes the addition of telomere DNA repeats
onto the 3' ends of linear chromosomes and plays a critical role in maintaining genome
stability. Unlike other reverse transcriptases, telomerase is unique in that it is a ...

[HTML] The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice

[HTML] from nih.govXZ Zhou, P Huang, R Shi, TH Lee… - The Journal of clinical …, 2011 - ncbi.nlm.nih.gov
... Copyright © 2011, American Society for Clinical Investigation. The telomerase inhibitor PinX1
is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. ...
Telomerase is activated in most human cancers and is critical for cancer cell growth. ...
Cited by 2 - Related articles - All 4 versions

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast

HC Ferreira, B Luke, H Schober, V Kalck… - Nature Cell …, 2011 - nature.com
Budding yeast telomeres are reversibly bound at the nuclear envelope through two partially redundant
pathways that involve the Sir2/3/4 silencing complex and the Yku70/80 heterodimer 1, 2 . To
better understand how this is regulated, we studied the role of SUMOylation in telomere ...
All 3 versions

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