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[HTML] from nih.govGS Zode, MH Kuehn, DY Nishimura… - The Journal of clinical …, 2011 - ncbi.nlm.nih.gov
Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma
(POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully
understood. Here, we report the development of a transgenic mouse model of POAG ...
KS Nair, M Hmani-Aifa, Z Ali, AL Kearney… - Nature Genetics, 2011 - nature.com
Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people 1, 2, 3 . Although
4 million people are bilaterally blind from ACG 4, 5 , the causative molecular mechanisms of
ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High ...
Cited by 2 - Related articles - All 3 versions
[PDF] from qimr.edu.auKP Burdon, S Macgregor, AW Hewitt, S Sharma… - Nature Genetics, 2011 - nature.com
We report a genome-wide association study for open-angle glaucoma (OAG) blindness using
a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 controls.
We identified associated loci at TMCO1 (rs4656461[G] odds ratio (OR) = 1.68, P = 6.1 × ...
Cited by 1 - All 5 versions
WD Ramdas, RCW Wolfs, A Hofman… - Archives of …, 2011 - Am Med Assoc
Methods Participants from the Rotterdam Study, a prospective population-based cohort
study, were considered eligible if they participated at both baseline and follow-up and if they
had no OAG at baseline. All participants underwent an identical ophthalmologic ...
Cited by 1 - Related articles - All 4 versions
JH Fingert - Eye, 2011 - nature.com
A substantial fraction of glaucoma has a genetic basis. About 5% of primary open angle glaucoma
(POAG) is currently attributed to single-gene or Mendelian forms of glaucoma (ie glaucoma caused
by mutations in myocilinor optineurin). Mutations in these genes have a high likelihood of ...
All 3 versions

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