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Periplasmic vestibule plays an important role for solute recruitment, selectivity, and gating in the Rh/Amt/MEP superfamily

U Akgun… - Proceedings of the National …, 2011 - National Acad Sciences
AmtB, a member of the Rh/Amt/MEP superfamily, is responsible for ammonia transport in Escherichia
coli. The ammonia pathway in AmtB consists of a narrow hydrophobic lumen in between hydrophilic
periplasmic and cytoplasmic vestibules. A series of molecular dynamics simulations ...
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… by (R)-N-(Benzimidazol-2-yl)-1, 2, 3, 4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep- …

DP Jenkins, D Strøbæk, C Hougaard… - Molecular …, 2011 - ASPET
Acting as a negative gating modulator, (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine
(NS8593) shifts the apparent Ca 2+ -dependence of the small-conductance Ca 2+ -activated
K + channels K Ca 2.1–2.3 to higher Ca 2+ concentrations. Similar to the positive K Ca ...
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Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor

MR Livesey, MA Cooper, JJ Lambert… - Journal of Biological …, 2011 - ASBMB
The determinants of single channel conductance (γ) and ion selectivity within eukaryotic pentameric
ligand-gated ion channels have traditionally been ascribed to amino acid residues within the
second transmembrane domain and flanking sequences of their component subunits. ...
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Orientation of μ-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding

JR McArthur, G Singh, ML O'Mara, D McMaster… - Molecular …, 2011 - ASPET
Mutant cycle analysis has been used in previous studies to constrain possible docking orientations
for various toxins. As an independent test of the bound orientation of μ-conotoxin PIIIA, a selectively
targeted sodium channel pore blocker, we determined the contributions to binding ...

ORIENTATION OF μ-CONOTOXIN PIIIA IN A SODIUM CHANNEL VESTIBULE, BASED ON ITS VOLTAGE DEPENDENCE OF BINDING

JR McArthur, G Singh, ML O'Mara, D McMaster… - Molecular …, 2011 - ASPET
From Department of Physiology and Pharmacology, and the Hotchkiss Brain Institute, (JRM,
DM, VO, RJF), ... School of Chemistry and Molecular Biosciences (MLO'M.), the University of
Queensland, Brisbane, Australia. ... Molecular Pharmacology Fast Forward. Published on ...
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