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Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax

JD Kanady, MT Dellinger, SJ Munger, MH Witte… - Developmental …, 2011 - Elsevier
Intraluminal valves are required for the proper function of lymphatic collecting vessels and large
lymphatic trunks like the thoracic duct. Despite recent progress in the study of lymphvasculogenesis
and lymphangiogenesis, the molecular mechanisms controlling the morphogenesis of ...
All 2 versions

[HTML] Novel Characterization of Lymphatic Valve Formation during Corneal Inflammation

[HTML] from plos.orgT Truong, E Altiok, D Yuen, T Ecoiffier… - PLoS ONE, 2011 - dx.plos.org
Lymphatic research has progressed rapidly in recent years. Though lymphatic dysfunction has
been found in a wide array of disorders from transplant rejection to cancer metastasis, to
date, there is still little effective treatment for lymphatic diseases. The cornea offers an ...
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Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

E Bazigou, OTA Lyons, A Smith, GE Venn… - J Clin …, 2011 - Am Soc Clin Investig
... these valves has obvious clinical implications (2). In addition, regulators of lymphatic valve
development, including the forkhead transcription factor Foxc2, the transmembrane ephrin-B2
ligand, and the cell matrix adhesion receptor integrin-α9, have recently been identified (3–5 ...

Lymphatic vascular morphogenesis in development, physiology, and disease

S Schulte-Merker, A Sabine… - The Journal of Cell …, 2011 - jcb.rupress.org
... Integrin α9 and its ligand fibronectin (FN) containing the EIIIA domain (FN-EIIIA) control later steps
of lymphatic valve formation (Bazigou et al., 2009). ... 2009. Integrin-alpha9 is required for fibronectin
matrix assembly during lymphatic valve morphogenesis. Dev. Cell. 17:175–186. ...
Cited by 1 - Related articles - All 2 versions

Determinants of valve gating in collecting lymphatic vessels from rat mesentery

MJ Davis, E Rahbar, AA Gashev… - American Journal of …, 2011 - Am Physiological Soc
Secondary lymphatic valves are essential for minimizing backflow of lymph and are presumed
to gate passively according to the instantaneous trans-valve pressure gradient. We hypothesized
that valve gating is also modulated by vessel distention, which could alter leaflet stiffness ...
Related articles - All 3 versions

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