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Essential glycan-dependent interactions optimize MHC class I peptide loading

[HTML] from nih.govPA Wearsch, DR Peaper… - Proceedings of the …, 2011 - National Acad Sciences
In this study we sought to better understand the role of the glycoprotein quality control machinery
in the assembly of MHC class I molecules with high-affinity peptides. The lectin-like chaperone
calreticulin (CRT) and the thiol oxidoreductase ERp57 participate in the final step of this ...
Cited by 3 - Related articles - All 5 versions

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide …

[PDF] from pitt.eduHJ Kwun, SR da Silva, H Qin, RL Ferris, R Tan… - Virology, 2011 - Elsevier
KSHV LANA1, a latent protein expressed during chronic infection to maintain a viral
genome, inhibits major histocompatibility complex class I (MHC I) peptide presentation in cis
as a means of immune evasion. Through deletional cloning, we localized this function to ...
Related articles - All 3 versions

Quantitative and qualitative influences of tapasin on the class I peptide repertoire

JJ Gorman, AW Purcell… - Journal of …, 2011 - espace.library.uq.edu.au
Tapasin is critical for efficient loading and surface expression of most HLA class I molecules.
The high level surface expression of HLA-B*2705 on tapasin-deficient 721.220 cells allowed
the influence of this chaperone on peptide repertoire to be examined. Comparison of ...
Cached - All 3 versions

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands

[PDF] from iu-bremen.deBP Dolan, JR Bennink… - Cellular and Molecular Life …, 2011 - Springer
Abstract It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis
to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of
infected cells. Here, we review the evidence for the contribution of DRiPs to antigen ...
Cited by 2 - Related articles - All 4 versions

Human Cytomegalovirus Disrupts the Major Histocompatibility Complex Class I Peptide-Loading Complex and Inhibits Tapasin Gene Transcription

A Halenius, S Hauka, L Dolken, J Stindt… - Journal of …, 2011 - Am Soc Microbiol
Major histocompatibility complex class I (MHC I) molecules present antigenic peptides for CD8
+ T-cell recognition. Prior to cell surface expression, proper MHC I loading is conducted by the
peptide-loading complex (PLC), composed of the MHC I heavy chain (HC) and β 2 - ...
Related articles - All 2 versions

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